West Ham will be hoping to make it two wins in a row after their recent victory at Nottingham Forest, while Tottenham will be looking to bounce back from their loss to Bournemouth and get their season back on track.
The London Stadium is set to be a full house, with a sell-out crowd expected to cheer on the Hammers and create a lively atmosphere.
West Ham's manager, Thomas Frank, will be looking to emulate the success of Ossie Ardiles and Tim Sherwood, who both won their first two top-flight away games in the Premier League.
However, West Ham's defence will need to be on their guard against Tottenham's star player, Jarrod Bowen, who has been in top form and has a hand in nine goals in his last nine appearances.
Bowen's impressive record makes him a key player to watch in the match, and West Ham's defence will need to be solid to prevent him from causing trouble.
On the other hand, Tottenham's manager, Graham Potter, is under pressure to get a win and silence the calls for his head, and a loss could make his situation even more precarious.
The match will also see the return of Mohammed Kudus, who left West Ham in the summer to join Tottenham, and his presence is expected to add to the excitement and tension of the game.
With both teams looking to secure a win, the match is set to be an intense and closely contested affair, with plenty of twists and turns to keep spectators on the edge of their seats.