Isak, who scored 27 goals in 42 appearances last season, has been the subject of speculation regarding his transfer. He has been linked with a move to Liverpool, but the club's recent signing of Hugo Ekitike may make it difficult for Isak to join the Reds.
Isak has three years remaining on his contract, giving Newcastle a strong bargaining position. However, he is unlikely to play for the team and his absence from the pre-season tour may signal the start of a difficult period for manager Eddie Howe.
Any bid exceeding the £125 million rejected by Newcastle earlier this month is likely to be accepted. Nevertheless, finding a buyer willing to meet this price is a challenge, and Isak may be forced to stay at Newcastle despite his intentions to leave.